Insulin-like Growth Factor I (IGF-I) with Placental Growth Factor (PlGF) ratio
This test measures the ratio of IGF-I, a hormone that supports growth and development, to PlGF, a protein involved in blood vessel formation. It helps assess how your body’s growth signals and blood supply are balanced, particularly in conditions affecting pregnancy or fetal development.
["This ratio helps evaluate growth hormone function and placental health during pregnancy."]
Key facts at a glance
- LOINC
- 38492-5
- Short code
- IGF-I SerPl-aCnc
- Synonyms
- IGF-I SerPl-aCnc
- Category
- hormone
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you’re experiencing complications related to pregnancy, such as gestational diabetes, preeclampsia, or concerns about fetal growth. It can also be used to monitor conditions like chronic hypertension or kidney disease that may affect these hormones and proteins.
What to Expect Before the Test
No special preparation is needed for this test. Blood is drawn from a vein, usually in your arm. You may feel a slight pinch when the needle is inserted, but it should only take a few minutes. If you’re pregnant, let your provider know about any medications or supplements you’re taking.
What the Results Mean
The test compares IGF-I and PlGF levels to determine the ratio. While specific reference ranges vary by lab, abnormal ratios may signal issues like poor placental function, growth restrictions, or metabolic disturbances. Your provider will interpret results in the context of your overall health and medical history.
Common Conditions Monitored
This test is often used to monitor pregnancies at high risk for complications, such as those with diabetes, hypertension, or multiple fetuses. It may also help assess conditions like chronic kidney disease or growth hormone deficiencies in non-pregnant individuals.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
IGF-I/PlGF Ratio
Frequently asked questions
What does an abnormal result mean for my health?
Do I need to fast before this test?
How long will it take to get my results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy