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Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) – Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-3, a protein that helps regulate growth factors important for cell growth and metabolism. It may be used to assess hormone balance or metabolic health.

Quick summary

["IGFBP-3 helps control growth signals in your body and may be checked if you have concerns about growth disorders or metabolic issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60010-6
Short code
IGF-I sp3 p chal SerPl-mCnc
Synonyms
IGF-I sp3 p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to abnormal growth hormone regulation, such as growth issues in children, metabolic disorders, or certain cancers. It could also be part of a broader evaluation for conditions affecting hormone function or liver health.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into a vein (typically in your arm) to draw blood. If you’re fasting, follow your provider’s instructions. Avoid strenuous activity or certain medications that could affect results.

What the Results Mean

Results are interpreted by your healthcare provider based on your medical history, symptoms, and other test results. Abnormal levels may suggest issues with growth hormone signaling, liver function, or other metabolic processes. Your provider will discuss findings in detail.

Common Conditions Monitored

This test may help diagnose or monitor conditions like: - Growth disorders in children, - Metabolic syndrome or diabetes, - Certain cancers (e.g., liver or kidney-related), - Hormone imbalances affecting growth or metabolism.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGFBP-3 Level

Frequently asked questions

What does an abnormal IGFBP-3 level indicate?
An abnormal result may signal potential underlying issues, such as liver problems, hormone imbalances, or conditions affecting growth or metabolism. Your provider will consider your full medical picture to interpret results accurately.
How long does it take to get test results?
Results are typically available within 1–3 business days, depending on your lab and insurance. Follow-up with your healthcare provider to discuss findings.
Can diet or medications affect IGFBP-3 levels?
Certain medications (e.g., steroids, thyroid hormones) or dietary factors (e.g., protein intake) may influence results. Avoid alcohol or certain supplements before testing if instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy