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Insulin-like Growth Factor Binding Protein 4 (IGFBP-4) Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-4, a protein that helps regulate insulin-like growth factors involved in cell growth and metabolism.

Quick summary

["IGFBP-4 helps balance growth signals in your body and may be checked if you have concerns about growth disorders or metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60009-8
Short code
IGF-I sp4 p chal SerPl-mCnc
Synonyms
IGF-I sp4 p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms or conditions linked to abnormal growth hormone or IGF signaling, such as growth issues in children, metabolic disorders, or certain hormonal imbalances. It may also be part of a broader evaluation for conditions like acromegaly or pituitary disorders.

What Does This Test Involve?

A blood sample is drawn from a vein, typically in your arm. The sample is processed to separate serum or plasma for testing. The test measures the concentration of IGFBP-4 protein in your blood.

What Are Common Uses?

This test is often used to assess how IGFBP-4 interacts with growth factors in conditions affecting growth, metabolism, or hormone regulation. It may also help monitor treatment responses in patients receiving growth hormone therapy.

What Does a Result Mean?

Results are not typically interpreted alone but are part of a larger clinical picture. Your provider will consider your symptoms, medical history, and other test results to determine if levels are within expected ranges or if further action is needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: IGFBP-4 plays a role in transporting and regulating IGFs, which influence growth, tissue repair, and metabolism. Abnormal levels may indicate underlying hormonal imbalances, metabolic disorders, or conditions affecting growth hormone signaling, guiding further diagnostic or therapeutic decisions.

Short name

IGFBP-4 Level

Frequently asked questions

What does a high IGFBP-4 level mean?
A high IGFBP-4 level may suggest conditions like hypothyroidism, liver disease, or certain metabolic disorders. It can also be influenced by medications or other health factors. Your provider will discuss findings in the context of your overall health.
What does a low IGFBP-4 level mean?
Low IGFBP-4 levels could be associated with growth hormone excess (e.g., acromegaly), certain genetic disorders, or other hormonal imbalances. This result should be evaluated alongside other tests and symptoms to understand its significance.
How often should I get this test?
Frequency depends on your medical condition, treatment plan, and provider recommendations. Some patients may need this test periodically to monitor changes in IGFBP-4 levels or response to treatment, while others may only need it once for diagnostic purposes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy