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Insulin-like Growth Factor Binding Protein 5 (IGFBP-5) Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-5, a protein that helps regulate how insulin-like growth factors interact with cells in your body.

Quick summary

["IGFBP-5 helps control growth and metabolism; levels may indicate hormonal balance or potential conditions affecting these processes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60008-0
Short code
IGF-I sp5 p chal SerPl-mCnc
Synonyms
IGF-I sp5 p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to growth hormone or IGFBP-5, such as growth disorders, metabolic issues, or suspected pituitary disorders. It may also be part of monitoring for conditions like acromegaly or growth hormone deficiency.

What to Expect Before the Test

No special preparation is typically needed. You may fast for 8–12 hours before the test if instructed, but always follow your provider’s guidance. Bring any medications you’re currently taking.

Test Process and Specimen Collection

A blood sample will be drawn from a vein in your arm by a healthcare professional. The blood is collected in a special tube and sent to the lab for analysis. The specimen is usually processed as serum.

What the Results Mean

Results provide a quantitative measure of IGFBP-5 in your bloodstream. While reference ranges vary by lab, elevated or low levels may signal underlying health concerns that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGFBP-5 Serum Level

Frequently asked questions

What does a high IGFBP-5 level mean?
A high IGFBP-5 level may suggest conditions affecting growth hormone metabolism, such as resistance to growth hormone or certain metabolic disorders. It could also be influenced by medications or hormonal imbalances. Always discuss results with your healthcare provider.
What does a low IGFBP-5 level mean?
Low IGFBP-5 levels might indicate potential growth hormone deficiency or other hormonal imbalances, though this isn’t definitive without clinical correlation. It could also reflect normal variation or other underlying health factors. Your provider will guide next steps.
Is fasting required for this test?
Fasting may be recommended, but always check with your provider before the test. Some labs may not require fasting, so follow their specific instructions to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy