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Insulin-like Growth Factor Binding Protein 6 (IGFBP-6) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-6, a protein that helps regulate how insulin-like growth factors interact with cells in your body.

Quick summary

["IGFBP-6 levels may help assess metabolic health and growth-related processes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60007-2
Short code
IGF-I sp6 p chal SerPl-mCnc
Synonyms
IGF-I sp6 p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to abnormal growth factor activity, such as growth disorders, metabolic syndrome, or certain hormonal imbalances. It could also be part of a broader evaluation for conditions affecting bone or muscle metabolism.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to fast for 8–12 hours before the test if instructed by your provider, but this is not always required for IGFBP-6. Bring any medications or supplements you’re currently taking to your appointment.

How the Test Is Performed

A blood sample is drawn from a vein in your arm by a healthcare professional. You may feel a small pinch when the needle is inserted, but the procedure usually takes less than five minutes. The blood sample is then sent to a lab for analysis.

What the Results Mean

Results are expressed as a mass concentration in the serum. While reference ranges vary by lab, elevated or low levels may signal potential metabolic, endocrine, or growth-related conditions. Your provider will interpret the results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGFBP-6 Level

Frequently asked questions

What causes IGFBP-6 levels to change?
IGFBP-6 levels can fluctuate due to hormonal changes, metabolic health, age, or certain medications. Conditions affecting growth factors, such as growth hormone disorders or metabolic syndrome, may also influence results. Stress, diet, or illness can sometimes impact these levels temporarily.
Do I need to prepare differently if I’m pregnant or breastfeeding?
If you’re pregnant or breastfeeding, inform your healthcare provider before the test. While no special fasting is required for IGFBP-6, they may adjust instructions based on your specific situation to ensure accuracy.
How long will I wait for my results?
Turnaround times vary by lab and healthcare setting. Some results may be available within a few days, while others could take up to two weeks or longer. Your provider will contact you once results are ready, so check in with them if you haven’t heard back within the expected timeframe.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy