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Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-1, a protein that helps regulate how insulin-like growth factors work in your body.

Quick summary

["IGFBP-1 helps balance growth signals and may reflect metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25758-4
Short code
IGF sp10 p chal SerPl-sCnc
Synonyms
IGF sp10 p chal SerPl-sCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IGFBP-1 Measure?

IGFBP-1 is one of several proteins that bind growth factors in your blood. It plays a role in controlling how these factors influence cell growth and metabolism. Levels can vary based on factors like nutrition, hormones, and health conditions.

Why Might Your Doctor Order This Test?

Your doctor may check IGFBP-1 levels if they suspect conditions affecting growth, metabolism, or liver function. It can also be part of monitoring for diabetes, kidney disease, or other metabolic disorders.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure IGFBP-1 concentration using a specialized immunoassay method.

What Does a Result Mean?

Results are not typically interpreted alone but in the context of your overall health, symptoms, and other test results. Abnormal levels may signal potential issues that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: IGFBP-1 plays a role in glucose metabolism and liver function. Low levels may be linked to conditions like diabetes or liver disease, while elevated levels could be associated with metabolic stress or certain hormonal imbalances.

Short name

IGFBP-1

Frequently asked questions

What causes changes in IGFBP-1 levels?
Changes in IGFBP-1 can occur due to dietary factors (like fasting or malnutrition), hormonal changes (such as pregnancy or thyroid issues), liver or kidney disease, or certain medications.
How long does it take to get results?
Results are usually available within 1 to 3 business days, depending on your lab’s processing time.
Can lifestyle changes affect IGFBP-1 levels?
Yes, diet, exercise, and hydration can influence IGFBP-1. For example, fasting or poor nutrition may lower levels, while proper hydration and balanced meals might help maintain normal ranges.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy