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Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-1, a protein that helps regulate how insulin-like growth factors work in your body. It may be checked to evaluate metabolic health or hormonal balance.

Quick summary

["IGFBP-1 helps control blood sugar and growth processes; levels can signal metabolic or endocrine concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25762-6
Short code
IGF sp14 p chal SerPl-sCnc
Synonyms
IGF sp14 p chal SerPl-sCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to abnormal growth factor activity, such as insulin resistance, gestational diabetes, or unexplained weight changes. It may also be part of a broader evaluation for metabolic syndrome or hormonal disorders.

What to Expect Before the Test

No special preparation is typically needed. You may fast for 8–12 hours before the test if instructed, but always follow your provider’s directions. Bring any medications you’re taking to discuss with them beforehand.

What the Test Involves

A blood sample will be drawn from a vein in your arm. The sample is sent to a lab to measure IGFBP-1 concentration. Results are usually available within 1–3 business days.

What the Results Mean

Results are compared to a reference range specific to your age, sex, and health status. Elevated levels may suggest insulin resistance or metabolic issues, while very low levels could indicate hormonal imbalances. Your provider will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IGFBP-1 Level

Frequently asked questions

How often should I get this test?
This test is usually ordered as needed for specific symptoms or evaluations, not as a routine screening. Your provider will determine frequency based on your health status and concerns.
Can lifestyle changes affect my IGFBP-1 levels?
Yes, diet, exercise, and weight management can influence IGFBP-1 levels. Reducing sugar intake, improving insulin sensitivity, and maintaining a healthy weight may help stabilize results.
Is this test covered by insurance?
Check with your insurance provider to confirm coverage, as it may depend on the reason for testing and your plan. Some tests are part of routine metabolic panels, while others may require prior authorization.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy