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Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-1, a protein that helps regulate growth factors in your body. It may be used to assess metabolic health or response to certain treatments.

Quick summary

["IGFBP-1 helps balance growth signals in your body and can be checked for metabolic or hormonal conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25763-4
Short code
IGF sp1 p chal SerPl-sCnc
Synonyms
IGF sp1 p chal SerPl-sCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to abnormal growth factor activity, such as diabetes, liver disease, or metabolic disorders. It could also be part of monitoring for hormonal treatments or metabolic conditions like preeclampsia in pregnancy.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to fast for 8–12 hours before the test if serum/plasma is used, but confirm with your lab or doctor. Avoid strenuous activity or certain medications that could affect results.

How the Test Is Performed

A blood sample will be drawn from a vein, usually in your arm. The blood is processed to separate serum or plasma for testing. The lab then measures the IGFBP-1 protein concentration using an immunoassay method.

What the Results Mean

Results are reported as a concentration value (e.g., micrograms per milliliter). While reference ranges vary by lab, elevated or low levels may signal conditions like diabetes, liver dysfunction, or metabolic stress. Your doctor will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGFBP-1 Serum Concentration

Frequently asked questions

How long does it take to get my results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Follow-up with your healthcare provider to discuss findings and next steps.
What does a ‘high’ or ‘low’ IGFBP-1 result mean?
A ‘high’ result may suggest conditions like preeclampsia, severe illness, or metabolic stress, while a ‘low’ result could relate to insulin resistance, diabetes, or liver issues. Your doctor will review your symptoms and other test results to explain.
Can diet or exercise affect IGFBP-1 levels?
Dietary changes (e.g., fasting) or exercise may influence IGFBP-1 temporarily, but results are usually interpreted in the context of your overall health. Avoid extreme dietary shifts before testing unless directed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy