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Insulin-like Growth Factor Binding Protein 6 (IGFBP-6) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP-6, a protein that helps regulate growth factors in your body. It may be used to assess metabolic health or evaluate conditions affecting growth hormone signaling.

Quick summary

["IGFBP-6 helps balance growth signals in your body and may be checked for metabolic or growth-related concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25768-3
Short code
IGF sp6 p chal SerPl-sCnc
Synonyms
IGF sp6 p chal SerPl-sCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms or conditions linked to abnormal growth hormone activity, such as metabolic disorders, bone health issues, or certain cancers. It could also be part of a broader evaluation for unexplained growth problems or metabolic disturbances.

What to Expect Before the Test

No special preparation is typically needed. You may fast for 8–12 hours before the test if instructed, but always follow your provider’s directions. Bring any medications or supplements you’re taking to your appointment.

What the Test Involves

A blood sample will be drawn from a vein, usually in your arm. The process is quick and generally comfortable. You may feel slight discomfort or a brief pinch, but it won’t last long.

What the Results Mean

Results are interpreted by your healthcare provider based on your overall health, symptoms, and medical history. Elevated or low levels may suggest conditions like metabolic syndrome, growth hormone resistance, or other metabolic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGFBP-6

Frequently asked questions

Will fasting affect my results?
Fasting may influence certain metabolic proteins like IGFBP-6, so follow your provider’s instructions about diet before testing. If unsure, ask whether to avoid food/drink for 8–12 hours before your appointment.
How long will I need to wait for results?
Results typically take 1–3 business days, depending on lab processing and your provider’s workflow. Follow-up may be scheduled if additional testing or evaluation is needed.
Can I take my medications before the blood draw?
If your provider prescribes medications, take them as usual unless instructed otherwise. Some medications may affect lab results, so always confirm with your healthcare team before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy