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Immunoglobulin G (IgG) Substance Concentration in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG), a type of antibody in your blood. IgG helps protect your body from infections and diseases.

Quick summary

["IgG levels help assess immune function and identify potential immune deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2467-9
Short code
IgG2 Ser-mCnc
Synonyms
IgG2 Ser-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Immunoglobulin G (IgG)?

IgG is the most common type of antibody in your blood. It plays a key role in fighting off infections by helping your immune system recognize and remember harmful substances, such as bacteria and viruses. IgG antibodies are produced by your immune system in response to exposure to pathogens (disease-causing organisms).

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms of a weakened immune system, such as frequent infections, slow wound healing, or unexplained fatigue. It can also be used to monitor immune responses in certain conditions, like chronic infections or autoimmune diseases.

When Is This Test Performed?

This test is typically done through a simple blood draw. You may be asked to fast for a few hours before the test, but this is not always required. The blood sample is sent to a lab for analysis, and results are usually available within a few days.

What Does the Test Result Mean?

Results are compared to standard ranges to determine if your IgG levels are within normal limits, lower than normal (hypogammaglobulinemia), or higher than normal. Low IgG levels may indicate an immune deficiency, while high levels could be due to chronic infections, certain medications, or other health conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Level

Frequently asked questions

What Are Common Causes of Low IgG Levels?
Low IgG levels can be caused by primary immune deficiencies (such as selective IgA deficiency or common variable immunodeficiency), chronic illnesses (like HIV/AIDS or liver disease), or certain medications. It may also occur in people with autoimmune diseases or those who have had their immune system weakened by treatments like chemotherapy.
What Are Common Causes of High IgG Levels?
High IgG levels are often seen in chronic infections (such as tuberculosis or hepatitis), certain autoimmune diseases (like rheumatoid arthritis or systemic lupus erythematosus), or as a side effect of some medications. In some cases, high IgG can be a normal finding, especially in older adults.
How Often Should I Get This Test?
The frequency of this test depends on your health condition and medical history. Your healthcare provider will determine how often you need retesting, whether it’s annually, every few years, or as needed based on symptoms and other test results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy