Immunoglobulin G (IgG) Heavy and Light Chain Free Light Chain Serum Protein Analysis
This test measures the levels of free heavy and light chains produced by your immune system’s antibodies. It helps detect conditions like multiple myeloma, where abnormal antibody production may occur.
["This test can help identify unusual antibody fragments that may signal serious health issues, such as cancer of the plasma cells."]
Key facts at a glance
- LOINC
- 17008-4
- Short code
- IgG/B-Tubulin Ser
- Synonyms
- IgG/B-Tubulin Ser
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 17
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like unexplained fatigue, frequent infections, or unexplained weight loss. It’s also used in diagnosing or monitoring conditions like multiple myeloma, lymphoma, or other blood disorders where abnormal antibody production is suspected.
What to Expect Before the Test
No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.
What the Test Results Mean
The test compares the levels of free heavy and light chains in your serum. Abnormal results may indicate conditions affecting your immune system, such as multiple myeloma or other plasma cell disorders. Your provider will discuss the results with you in detail.
Common Conditions Monitored
This test is primarily used to monitor multiple myeloma, a cancer of plasma cells in the bone marrow. It can also help diagnose or evaluate conditions like Waldenström macroglobulinemia or other immunoproliferative disorders.
Reference range
NCBI: NSE 0-17 ng/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal levels of free light chains can signal multiple myeloma or other plasma cell disorders. High levels of one type of light chain (kappa or lambda) may indicate an imbalance in immune function, which can be linked to certain cancers or autoimmune diseases. Your provider will use these results alongside other tests and symptoms to make a diagnosis or guide treatment decisions.
Short name
IgG Free Light Chain Profile (Serum)
Frequently asked questions
What does an abnormal result mean?
How often should I get this test?
Does this test hurt?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy