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Immunoglobulin Kappa Light Chain in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of kappa-type light chains found in your blood serum. Light chains are small protein fragments produced when your immune system makes antibodies.

Quick summary

["Light chains help identify certain immune system conditions, including multiple myeloma or other plasma cell disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74868-1
Short code
IgG Kappa/G lambda SerPl
Synonyms
IgG Kappa/G lambda SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Done?

Your healthcare provider may order this test if you have symptoms like unexplained fatigue, frequent infections, bone pain, or kidney problems. It may also be used to monitor conditions like multiple myeloma or other blood disorders where abnormal antibody production is suspected.

What Does the Result Mean?

Results can vary widely and are often interpreted in the context of your overall health and other test results. Elevated levels may suggest conditions like multiple myeloma or monoclonal gammopathy, while abnormal patterns could indicate immune system dysfunction.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is then processed to separate the serum, which is sent to the lab for analysis. This test does not require fasting.

Common Conditions Monitored or Diagnosed

This test is often used to diagnose or monitor conditions such as multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), or other plasma cell disorders. It can also help detect kidney problems related to abnormal protein production.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgK Light Chain (Serum)

Frequently asked questions

What is a normal range for this test?
There is no single normal range for light chain levels alone. Results are typically evaluated in relation to your clinical picture, other lab tests, and symptoms. Your healthcare provider will interpret the result based on these factors.
Can diet or lifestyle affect this test?
Diet or lifestyle factors generally do not directly affect light chain levels in serum. However, conditions like kidney disease or infections may influence protein levels, so it’s important to discuss any symptoms or health changes with your provider.
How often should this test be repeated?
The frequency of retesting depends on your medical condition. If you have a known disorder like multiple myeloma, your provider may recommend regular monitoring to track changes in your light chain levels and overall health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy