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Immunoglobulin G (IgG) Subclass 1 and 3 Quantification (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures specific types of antibodies called immunoglobulin G (IgG) subclasses 1 and 3 in your blood, which play key roles in immune response.

Quick summary

["IgG subclasses help identify immune system function and potential deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96480-9
Short code
IgLON5 IgG Titr CSF IF
Synonyms
IgLON5 IgG Titr CSF IF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82977
SNOMED
3110003
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like frequent infections, unusual reactions to vaccines, or conditions affecting your immune system. It could also be part of an evaluation for autoimmune diseases or certain genetic disorders.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Test Results Mean

Results show the concentration of IgG subclass 1 and 3 in your blood. Lower-than-expected levels may suggest immune system issues, while higher levels could indicate certain infections or conditions.

Common Conditions Linked to Results

Abnormal IgG subclass levels may be linked to conditions like chronic infections, autoimmune diseases (e.g., lupus), or inherited immune deficiencies. Your provider will discuss findings in the context of your health history.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG subclass testing

Frequently asked questions

What does IgG subclass testing involve?
This test measures specific antibody types in your blood using a blood draw. It helps assess immune function and identify potential deficiencies or disorders.
How often should I get this test?
Your provider will determine frequency based on your symptoms, medical history, or treatment plan. Follow-up may be needed if results suggest an immune issue.
Can diet affect IgG subclass levels?
Dietary factors may indirectly influence immune health, but they don’t directly alter IgG subclass levels. Focus on overall nutrition and hydration for immune support.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy