Skip to content

Immunoglobulin M (IgM) Antibody to Human Urinary Protein (HUP) – 24-Hour Collection

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of IgM antibodies against a specific urinary protein over a 24-hour period. It may be used to assess kidney function or detect certain urinary tract conditions.

Quick summary

["This test helps evaluate kidney health or urinary system issues by tracking antibody responses to urinary proteins over a full day’s urine output."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44600-5
Short code
IgM 24h Ur Ql IFE
Synonyms
IgM 24h Ur Ql IFE
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immunofixation
CPT
82784
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like frequent urination, blood in urine, or signs of kidney problems. It could also be used to monitor conditions affecting urinary proteins or immune responses in urine.

What to Expect Before the Test

You’ll need to collect all urine for a full 24 hours in a special container. Drink plenty of fluids to ensure complete collection. Avoid certain medications or foods that might interfere with results.

How the Test Works

The collected urine is analyzed to detect IgM antibodies against urinary proteins. The method typically involves immunoassay to measure antibody levels accurately.

Possible Results and Interpretation

Results may indicate elevated antibody levels if kidney function is impaired or if there’s an immune response affecting urinary proteins. Normal results suggest no significant antibody presence.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated IgM to urinary protein levels may signal kidney damage, urinary tract infections, or other conditions affecting protein excretion. Low or absent levels could suggest normal kidney function or specific immune system responses.

Short name

IgM to Urinary Protein (HUP) 24h

Frequently asked questions

What causes abnormal IgM antibody levels in urine?
Abnormal levels may arise from kidney diseases (e.g., glomerulonephritis), urinary tract infections, or conditions affecting protein excretion. Rarely, it could reflect immune-mediated responses.
How often should this test be repeated?
Your provider will determine frequency based on your symptoms and test results. Repeat testing may be needed if initial results are unclear or if monitoring a condition.
Can diet or medications affect this test?
Yes, certain medications (e.g., NSAIDs) or foods (e.g., high-protein diets) may influence urinary protein levels. Follow your provider’s instructions to avoid interferences.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy