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Immunoglobulin M (IgM) Antibody to Tissue Transglutaminase (TTG) - Serology

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that may indicate an autoimmune response targeting a protein found in the intestines, often linked to certain digestive conditions.

Quick summary

["Helps assess potential celiac disease or related autoimmune conditions by detecting specific antibodies in your bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10493-5
Short code
IgM Ag Tiss Ql ImStn
Synonyms
IgM Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgM antibodies against tissue transglutaminase (TTG), an enzyme involved in gut tissue repair. These antibodies can signal an immune reaction that may contribute to inflammation in the intestines.

Why It’s Ordered

Your healthcare provider may recommend this test if you have symptoms like persistent diarrhea, abdominal pain, or unexplained weight loss, or if you’ve been diagnosed with conditions like celiac disease or non-celiac gluten sensitivity.

Common Uses

This test is often used as part of a broader evaluation for autoimmune gastrointestinal disorders, particularly when other tests like endoscopy or genetic screening are considered.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The sample is processed into serum (liquid part of blood after clotting) for testing. No special preparation is needed, but fasting may not be required unless instructed by your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgM Anti-TTG (Serum)

Frequently asked questions

IgM anti-TTG antibodies are commonly elevated in individuals with active celiac disease or related autoimmune conditions. While not definitive alone, they are highly suggestive when combined with clinical symptoms and other diagnostic findings.
This test helps differentiate between conditions like celiac disease, gluten sensitivity, and other gastrointestinal disorders by identifying an immune response to gluten-related proteins.
What does a positive result mean?
A positive result indicates the presence of IgM antibodies against TTG, which may suggest an autoimmune reaction in the intestines. Further testing, such as an endoscopy with biopsy, may be needed to confirm a diagnosis.
How soon will I get results?
Results are typically available within 3–5 business days, depending on lab processing times. Your healthcare provider will discuss the results with you during your follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy