Skip to content

Interleukin-12 (IL-12) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of interleukin-12, a protein involved in immune system responses, in your blood serum. It may be used to assess immune function or evaluate conditions affecting inflammation.

Quick summary

["IL-12 helps regulate immune cells and may indicate immune activity or disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17022-5
Short code
Il1+2 SerPl-aCnc
Synonyms
Il1+2 SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms or conditions linked to immune system activity, such as chronic inflammation, autoimmune diseases, infections, or certain cancers. It may also be part of monitoring for immune-related treatments.

What to Expect Before the Test

No special preparation is typically needed. You may have blood drawn from a vein in your arm. If you’re on blood-thinning medication, let your provider know before the test.

What the Results Mean

Interpreting IL-12 levels involves comparing your result to a reference range provided by your lab. Elevated levels may suggest overactive immune responses, while lower levels could indicate immune suppression or other conditions.

Common Conditions Monitored

IL-12 testing is less common but may be used in research or specialized care for conditions like chronic inflammation, certain infections, or immune-related cancers. It’s not routinely ordered for general health screening.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IL-12 Serum Level

Frequently asked questions

What causes IL-12 levels to change?
IL-12 levels can fluctuate due to infections, autoimmune diseases, certain medications (like biologics), or immune system overactivity. Chronic stress or illness may also temporarily affect its concentration.
Is IL-12 testing covered by insurance?
Coverage depends on your diagnosis, treatment plan, and insurance provider. If ordered for a specific medical reason (e.g., autoimmune disease monitoring), check with your insurer or provider for details.
Can diet or supplements affect IL-12 levels?
Dietary factors or supplements are less likely to directly impact IL-12 levels, but a balanced diet supports overall immune function. If you’re on supplements, discuss potential interactions with your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy