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: Interleukin-1, Serum or Plasma, Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

: This test measures the concentration (mass per volume) of interleukin-1, an inflammatory signaling protein, in a blood sample (serum or plasma). It is used mainly in research and specialized settings to assess immune and inflammatory activity.

Quick summary

[": Interleukin-1 is an inflammation-related cytokine, and this test measures how much of it is present in your blood by mass concentration."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34407-7
Short code
Il1 SerPl-mCnc
Synonyms
Il1 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What Is Interleukin-1?

: Interleukin-1 (IL-1) is a small protein made by immune cells that helps coordinate the body's inflammatory response. It acts as a chemical messenger, signaling other cells during infection, injury, and certain inflammatory conditions.

: Why Might This Test Be Ordered?

: Measurement of IL-1 is not a routine clinical test and is used mostly in research and specialized immunology or inflammatory-disease evaluation. When ordered, it is intended to help understand the level of inflammatory signaling activity rather than to diagnose a specific condition on its own.

: How the Sample Is Collected

: A blood sample is drawn from a vein, typically from your arm, and the laboratory measures IL-1 in either serum or plasma. No special preparation is usually needed, though your care team will give you any specific instructions.

: Understanding Your Result

: Results are reported as a mass concentration in the blood. Because IL-1 testing is specialized and not standardized for general clinical use, your result should always be interpreted by your healthcare provider alongside your symptoms, history, and other tests rather than compared to fixed cutoffs.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: IL-1

Frequently asked questions

: Is an interleukin-1 blood test a routine test?
: No. IL-1 measurement is largely a research and specialty test and is not part of standard routine blood panels.
: Does a high IL-1 level mean I have a specific disease?
: Not necessarily. IL-1 is an inflammation marker, and levels can change with many conditions. A result must be interpreted by your provider in the context of your overall health and other findings.
: Do I need to fast before this test?
: Usually no special preparation is required, but follow any instructions your healthcare provider or laboratory gives you.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy