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Interleukin-2 (IL-2) quantitative concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of interleukin-2, a protein involved in immune system signaling, present in your blood.

Quick summary

["IL-2 levels help assess immune response and potential inflammation or autoimmune activity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
70077-3
Short code
Il2 CSF-mCnc
Synonyms
Il2 CSF-mCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is Interleukin-2?

Interleukin-2 (IL-2) is a cytokine produced primarily by activated T-cells that plays a critical role in regulating the immune response. It stimulates the growth and activity of other immune cells, including T-cells, B-cells, and natural killer cells. Elevated levels may indicate an active immune reaction, while lower levels could suggest immune suppression or dysfunction.

Why Might You Need This Test?

Doctors may order this test to evaluate immune function, diagnose autoimmune diseases, monitor immune-related conditions (e.g., certain cancers treated with IL-2 therapy), or investigate symptoms like fatigue, infections, or unexplained inflammation.

Common Uses in Healthcare

This test is often used in research or specialized clinical settings where immune monitoring is critical, such as in studies of immune checkpoint inhibitors, autoimmune disorders, or immune deficiencies.

What Does the Test Involve?

A blood sample is drawn from a vein, typically in your arm. The sample is processed to separate serum or plasma, which is then analyzed for IL-2 concentration using a sensitive immunoassay method.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IL-2 Serum/Plasma

Frequently asked questions

How often do I need this test?
The frequency depends on your medical condition and treatment plan. Your healthcare provider will determine how often this test is needed based on your individual care needs.
What are normal IL-2 levels?
There are no universally standardized reference ranges for IL-2 in serum/plasma due to its variable production and measurement challenges. Your results will be interpreted in the context of your clinical situation.
Can lifestyle or diet affect IL-2 levels?
IL-2 is primarily produced by immune cells in response to stimuli like infections or inflammation. While diet and lifestyle factors may influence immune function indirectly, they do not directly alter IL-2 levels in blood samples.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy