Interleukin-2 Receptor (CD25) Substance Concentration, Serum or Plasma
This test measures the amount of interleukin-2 receptor protein in your blood. It helps assess immune system activity, particularly in conditions involving T-cell activation.
["This test may help diagnose or monitor autoimmune diseases, infections, or certain cancers."]
Key facts at a glance
- LOINC
- 23884-0
- Short code
- Il2Recep Tiss Ql ICA
- Synonyms
- Il2Recep Tiss Ql ICA
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 8.5
- Ref high
- 10.5
- Critical range
- 6 N/A – 14 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ica
- CPT
- 82310
- SNOMED
- 110744001
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The interleukin-2 receptor (CD25) is a protein that binds to interleukin-2, a signaling molecule important for T-cell function. Elevated levels may indicate an overactive immune response, such as in autoimmune diseases or chronic infections.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms or conditions linked to abnormal immune activity, such as rheumatoid arthritis, lupus, or certain types of lymphoma. It can also be used to monitor treatment responses in these cases.
Sample Collection and Preparation
A blood sample is drawn from a vein, usually in your arm. The sample is collected in a tube containing an anticoagulant to separate serum or plasma from blood cells. This is sent to a lab for testing.
Common Conditions Monitored
Elevated levels of IL-2 receptor may be associated with conditions like severe autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis), chronic infections (e.g., HIV), or certain cancers (e.g., T-cell lymphomas).
Reference range
Adult: 8.5-10.5 mg/dLN/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
High IL-2 receptor levels often signal an overactive immune response or abnormal T-cell proliferation. This can guide treatment decisions, such as adjusting medications for autoimmune diseases or evaluating the need for further diagnostic testing in suspected malignancies.
Short name
IL-2 Receptor (CD25)
Frequently asked questions
What does a high or low IL-2 receptor level mean?
How long does it take to get results?
Can diet or lifestyle affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy