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Interleukin-5 (IL-5) concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of interleukin-5, a protein involved in regulating immune responses, particularly in the production of B cells and eosinophils.

Quick summary

["IL-5 helps your immune system respond to allergies and chronic inflammatory conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4654-0
Short code
Il5 SerPl-aCnc
Synonyms
Il5 SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Interleukin-5 Used For?

IL-5 is primarily measured to assess immune function, particularly in conditions where eosinophils (a type of white blood cell) are elevated. It may also be evaluated in allergic reactions, certain autoimmune diseases, or after immune therapy.

How Is This Test Performed?

A blood sample is drawn from a vein, typically in your arm. The blood is then processed to separate serum or plasma, which is sent to a lab for testing using an immunoassay method to detect IL-5 levels.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms of allergies, asthma, or other immune-related conditions. It may also be used to monitor treatment responses in patients undergoing therapies that target immune pathways.

What Do Results Mean?

Results are not typically provided as a single reference range, as IL-5 levels can vary widely depending on the individual’s health status and medical condition. Elevated levels may indicate an active immune response, such as in allergic reactions or certain inflammatory diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IL-5 Serum/Plasma

Frequently asked questions

What causes abnormal IL-5 levels?
Abnormal IL-5 levels can result from conditions like allergic reactions, asthma, eosinophilic granulomatosis with polyangiitis, or other immune-mediated disorders. Certain medications or treatments that modulate the immune system may also affect IL-5 levels.
How often should I expect this test?
The frequency of this test depends on your medical condition and treatment plan. Your healthcare provider will determine how often you need testing based on your specific needs, such as monitoring disease progression or response to therapy.
Can lifestyle changes affect IL-5 levels?
While lifestyle factors like diet, stress, and exercise can influence overall immune function, their direct impact on IL-5 levels is not well-documented. Always follow your healthcare provider’s advice regarding lifestyle modifications related to your condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy