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Interleukin-8 (IL-8) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of interleukin-8, a protein your body produces in response to inflammation or infection.

Quick summary

["IL-8 helps your immune system fight infections and signals inflammation, often checked if you have symptoms of illness or suspected inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
99769-2
Short code
Il8 CSF-mCnc
Synonyms
Il8 CSF-mCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test to evaluate symptoms such as fever, pain, swelling, or other signs of inflammation. It can also help diagnose conditions like infections, autoimmune diseases, or chronic inflammatory disorders. Sometimes, it’s used to monitor treatment progress for conditions affecting the immune system or inflammation.

What to Expect Before the Test

No special preparation is usually needed. You may fast before the test if it’s done in the morning, but your provider will let you know. Bring any medications you’re taking, as some may affect results. Avoid strenuous activity or excessive exercise 24 hours before the test.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood sample is then sent to a lab for analysis.

What the Results Mean

Results can vary depending on your health condition. High levels of IL-8 often indicate inflammation or infection, while normal or low levels may suggest no active inflammation. Your provider will interpret the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IL-8 Level

Frequently asked questions

What Are Common Causes of Elevated IL-8 Levels?
Elevated IL-8 levels are commonly seen in infections (such as bacterial or viral), acute inflammation, autoimmune diseases (like rheumatoid arthritis or lupus), and conditions involving tissue damage or stress. Chronic conditions such as asthma, COPD, or certain cancers may also be associated with higher IL-8 levels.
What Are Common Causes of Low IL-8 Levels?
Low IL-8 levels are less common and may occur in cases of severe immune suppression, certain genetic disorders affecting cytokine production, or during recovery from acute inflammation. Your provider will consider other factors, such as medications that suppress immune function.
How Often Should IL-8 Be Monitored?
IL-8 is typically not routinely monitored unless you have a known inflammatory condition or symptoms suggesting inflammation. Your provider may order it periodically if you’re under treatment for a condition linked to IL-8, such as an autoimmune disease or infection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy