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Immunoassay for Anti-Cardiolipin Antibodies (IgG)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies in your blood that target a specific protein found in cell membranes, often linked to certain autoimmune conditions.

Quick summary

["Helps assess risk for autoimmune disorders like lupus or other connective tissue diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75239-4
Short code
IMA Ser-aCnc
Synonyms
IMA Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

Anti-Cardiolipin antibodies (IgG) are proteins your immune system produces in response to the cardiolipin protein, which is normally found in cell membranes. This test detects their presence in your blood. These antibodies can be associated with autoimmune diseases, such as lupus, or other conditions like antiphospholipid syndrome.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms of autoimmune diseases (e.g., joint pain, fatigue, rash) or if you have a history of blood clots, recurrent miscarriages, or other unexplained health issues. It can also be part of a broader evaluation for conditions like systemic lupus erythematosus (SLE).

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The sample is then sent to a lab for testing using an immunoassay method, which detects the antibodies in your blood with high sensitivity.

What Do the Results Mean?

Results are not interpreted alone but in the context of your symptoms, medical history, and other test results. Elevated levels may suggest an increased risk for autoimmune conditions or other related disorders, but further evaluation is needed to confirm a diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Anti-Cardiolipin Antibodies (IgG)

Frequently asked questions

What does a positive or elevated result mean?
A positive or elevated result suggests an increased likelihood of certain autoimmune conditions or related disorders, but it does not confirm a diagnosis on its own. Your healthcare provider will review the results alongside your medical history, symptoms, and other tests to determine the next steps.
How often should I get this test?
The frequency depends on your healthcare provider’s recommendations. If you have an ongoing condition like lupus or another autoimmune disorder, they may recommend periodic testing to monitor your health and response to treatment. If this is a one-time screening, follow-up may not be necessary unless symptoms change.
Can lifestyle changes affect this test result?
While certain medications (e.g., steroids, immunosuppressants) or autoimmune treatments may influence antibody levels, lifestyle factors like diet, stress, or physical activity generally do not directly affect this specific test result. Always discuss any changes in your treatment plan with your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy