Skip to content

Neutrophil count in cerebrospinal fluid (CSF) by automated cell differential

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your cerebrospinal fluid (CSF). Neutrophils help fight infections and inflammation in the central nervous system.

Quick summary

["Assessing your CSF for neutrophil levels can help diagnose or monitor conditions affecting the brain or spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
69006-5
Short code
Imm Granulocytes NFr CSF
Synonyms
Imm Granulocytes NFr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms like severe headaches, neck stiffness, fever, or neurological issues that suggest an infection or inflammation in the brain or spinal cord. It can also be part of a routine evaluation for conditions like meningitis, encephalitis, or other infections.

What to Expect Before the Test

You’ll likely undergo a lumbar puncture (spinal tap) where a small needle is inserted into your lower back to collect CSF. The procedure is usually quick and done while you’re lying on your side. You may feel a brief pinch, but it’s generally not painful.

What the Test Results Mean

High neutrophil counts in CSF may indicate an infection (such as bacterial meningitis) or inflammation. Low or normal counts could suggest viral infections, autoimmune conditions, or other non-infectious causes. Your doctor will interpret results in the context of your symptoms and overall health.

Common Conditions Monitored

This test helps diagnose or monitor conditions like bacterial meningitis, encephalitis, subarachnoid hemorrhage, or other inflammatory or infectious processes in the central nervous system.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Neutrophils in CSF

Short name

CSF Neutrophils

Frequently asked questions

What causes elevated neutrophil levels in CSF?
Elevated neutrophil counts in CSF are most commonly seen in bacterial infections (e.g., bacterial meningitis), where these cells rush to the site of infection to fight pathogens. They can also appear in severe inflammatory conditions or after traumatic injury to the spinal cord.
What does a normal or low neutrophil count in CSF suggest?
A normal or low neutrophil count in CSF often points toward viral infections, autoimmune diseases (like Guillain-Barré syndrome), or non-infectious causes such as certain types of headaches or spinal issues. Your doctor will consider other test results and symptoms to guide diagnosis.
How often should this test be repeated?
The frequency depends on your symptoms and diagnosis. If you’re being monitored for an ongoing condition (e.g., chronic meningitis), your doctor may recommend follow-up tests at intervals they determine appropriate for your care plan.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy