Immunoglobulin Response Profile (Serum/Plasma) – Functional Class
This test measures how well your immune system produces and uses certain antibodies (immunoglobulins) to fight infections. It helps assess immune function after vaccination or in conditions where the immune response may be impaired.
["This test evaluates your body’s ability to mount an effective antibody response, useful for diagnosing or monitoring immune deficiencies or vaccine effectiveness."]
Key facts at a glance
- LOINC
- 54225-8
- Short code
- Immune response Pnl Spec FC
- Synonyms
- Immune response Pnl Spec FC
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 17
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- flow-cytometry
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you’ve had a recent vaccination (e.g., flu, COVID-19) and your immune system hasn’t produced enough antibodies to protect you. It’s also used in people with weakened immune systems (e.g., from HIV, chemotherapy, or autoimmune diseases) to check if their immune response is working as expected.
What to Expect Before the Test
No special preparation is needed. A blood sample will be drawn from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. If you’re on blood-thinning medication, let your doctor know before the test.
What the Test Results Mean
Results compare your antibody levels to expected ranges for a healthy immune response. Low levels may indicate an impaired immune response, while normal or high levels suggest a typical reaction. Your doctor will interpret results in the context of your medical history and symptoms.
Common Conditions Monitored
This test helps diagnose or monitor conditions like primary immunodeficiency, HIV/AIDS, or chronic illnesses that affect antibody production. It’s also used to evaluate vaccine effectiveness in people with weakened immune systems.
Reference range
NCBI: NSE 0-17 ng/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Immunoglobulin Function Test
Frequently asked questions
How Long Does It Take to Get Results?
What If My Results Are Abnormal?
Does This Test Cover All Antibodies?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy