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Cerebrospinal Fluid (CSF) Protein Profile by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord) using electrophoresis, a method that separates proteins based on size and charge.

Quick summary

["Helps identify abnormal protein patterns that may signal neurological conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60607-9
Short code
IMPA (1L-GoMe) (constructed) Skull XR
Synonyms
IMPA (1L-GoMe) (constructed) Skull XR
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-measured
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like headaches, neurological issues, or a history of conditions such as multiple sclerosis, meningitis, or brain tumors. It can also be used to monitor certain treatments or investigate unexplained neurological symptoms.

What to Expect Before the Test

You’ll likely have a small amount of fluid drawn from your spine (lumbar puncture) using a needle. The procedure is usually quick and may cause mild discomfort. No special preparation is needed, but inform your doctor about any medications you’re taking.

What the Test Results Mean

Electrophoresis separates CSF proteins into bands, showing relative amounts of albumin, globulins, and other proteins. Abnormal patterns (e.g., high globulins) may indicate inflammation, infection, or tumors. Results are interpreted by a healthcare provider based on your symptoms and medical history.

Common Conditions Monitored

This test helps diagnose or monitor conditions like multiple sclerosis, Guillain-Barré syndrome, meningitis, subarachnoid hemorrhage, or certain brain tumors. It may also assess protein leakage or immune responses in the central nervous system.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CSF Protein Electrophoresis

Frequently asked questions

What preparation do I need before the test?
No special preparation is required, but avoid heavy exercise or caffeine 24 hours before the procedure. Tell your doctor about any medications, especially blood thinners, as they may affect the fluid collection.
How long will I need to stay for the test?
The procedure typically takes about 15–30 minutes, but you may need to stay in the clinic for observation afterward. Recovery is usually immediate, with mild soreness at the injection site.
Can I drink or eat before the test?
You can eat and drink normally unless instructed otherwise by your provider. Avoid alcohol or caffeine before the lumbar puncture, as they may affect fluid clarity or your symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy