Endogenous Creatinine Clearance (from 24-hour urine collection)
This test measures how well your kidneys filter waste products, specifically creatinine, over a 24-hour period using urine samples.
["It helps assess kidney function and how efficiently your kidneys remove waste from your blood."]
Key facts at a glance
- LOINC
- 19777-2
- Short code
- Indications Endscpy
- Synonyms
- Indications Endscpy
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 17
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- endoscopy
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if they suspect kidney disease, monitor kidney function over time, or evaluate how well a kidney transplant or other kidney treatments are working. It can also help diagnose conditions like chronic kidney disease or determine if medications are affecting kidney function.
How the Test Works
You’ll collect all your urine over 24 hours in a special container. Blood is also drawn to measure your creatinine levels in the blood. The test compares how much creatinine is in your urine versus your blood to calculate clearance.
Sample Collection Process
You’ll start the collection right after waking up, emptying your bladder first. You’ll keep a record of every urine output throughout the day and night. Blood is drawn at the start and end of the collection period.
Preparation
No special preparation is needed, but you should avoid certain medications that might affect kidney function. Drink enough water to help your kidneys produce urine, but don’t overhydrate.
Reference range
NCBI: NSE 0-17 ng/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Endogenous creatinine clearance is a key measure of kidney function. Lower than expected values may indicate kidney damage or disease, while higher values could suggest overhydration or other conditions affecting kidney function. It’s often used alongside other tests to get a full picture of kidney health.
Short name
None
Frequently asked questions
What does a low creatinine clearance mean?
How often is this test done?
Can I eat or drink anything before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy