Skip to content

Information Source for Laboratory Test Results (Qualitative Immunoassay for Donor-Specific Antibody Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies in your blood that may react with donated blood components, helping ensure compatibility before transfusion.

Quick summary

["Helps prevent transfusion reactions by identifying potential antibody risks in donated blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71536-7
Short code
INFORMATIONSOURCE
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
esrd
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re scheduled for a blood transfusion or if you have a history of transfusion reactions. It’s also used to screen donated blood for compatibility with patients who may be at higher risk of adverse reactions.

How the Test Works

A small blood sample is taken and tested using an immunoassay method to detect specific antibodies that could react with donor blood components. The result is qualitative—meaning it’s either positive (antibodies present) or negative (antibodies not detected).

Sample Collection and Processing

The test uses whole blood drawn from a vein. The sample is processed and analyzed in a laboratory setting to identify the presence of antibodies without providing a specific numeric value.

What to Expect Before the Test

No special preparation is needed. You may have a slight bruise or soreness at the injection site, but this usually fades quickly. If you’re scheduled for a blood donation, follow your donor center’s guidelines for fasting or other preparations.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Donor Antibody Screen (Qualitative)

Frequently asked questions

What does a positive result mean?
A positive result means antibodies were found in your blood that could potentially react with donor blood components. This doesn’t necessarily mean you’ll have a reaction during a transfusion, but it may require additional testing to ensure safe blood matching.
Will I need to avoid certain foods or medications before this test?
No special diet or medications are required. However, if you’re scheduled for a blood donation, follow your donor center’s instructions regarding fasting or other preparations.
Can this test be done on urine or saliva instead of blood?
No, this test specifically uses blood to detect antibodies. If you’re concerned about blood draws, discuss alternatives with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy