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C-reactive protein (CRP) assay, high-sensitivity

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is responding to inflammation, often triggered by injury, infection, or illness.

Quick summary

A high hs-CRP level may signal inflammation that your doctor needs to address.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
103978-3
Short code
INFORMATION-TO-TELL-DOCTORS-IF-YOU-HAVE-A-SUDDEN-INJURY-OR-ILLNESS-WITH-A-GOOD
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
reported
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why hs-CRP Matters in Sudden Illness or Injury

hs-CRP (high-sensitivity C-reactive protein) is a blood test that helps doctors detect subtle signs of inflammation—even when other symptoms aren’t obvious. It’s particularly useful after sudden injuries or illnesses because inflammation can occur before you feel symptoms like pain or fever.

How the Test Works

Your blood sample is tested for tiny amounts of CRP, a protein produced by your liver in response to inflammation. The test uses a sensitive method to measure these levels, often in milligrams per liter (mg/L).

When Your Doctor Might Order This Test

Doctors may order hs-CRP if you’ve had a recent injury (like a broken bone or soft tissue trauma), surgery, or illness (such as a viral infection or flare-up of a chronic condition). It can also help monitor long-term inflammation in conditions like heart disease or autoimmune disorders.

What the Results Mean

Results are typically reported as a numerical value, but your doctor will interpret them based on your overall health and symptoms. Very high levels may indicate severe inflammation, while low levels suggest minimal inflammation. Your doctor will discuss what your result means in the context of your care plan.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Inflammation as a Hidden Risk Factor

Short name

hs-CRP

Frequently asked questions

What causes elevated CRP levels?
Elevated CRP can be caused by many things, including infections (like pneumonia or urinary tract infections), injuries, surgeries, or autoimmune diseases. It can also rise after stress, certain medications, or even routine activities like exercise. Chronic inflammation—even without obvious symptoms—may increase the risk of long-term health problems like heart disease or diabetes.
Can I lower my CRP levels naturally?
Yes! Lifestyle changes like eating anti-inflammatory foods (such as fruits, vegetables, and omega-3 fatty acids), staying physically active, managing stress, and avoiding smoking can help lower CRP levels. Your doctor may also recommend specific treatments if inflammation is linked to an underlying condition.
How soon after an injury or illness should I get this test?
Timing depends on your doctor’s orders. Some tests are done shortly after an event (like 24 hours post-injury), while others may be scheduled later to monitor healing. Follow your healthcare provider’s instructions carefully.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy