C-reactive protein (CRP) assay, high-sensitivity
This test measures a protein in your blood that rises when your body is responding to inflammation, often triggered by injury, infection, or illness.
A high hs-CRP level may signal inflammation that your doctor needs to address.
Key facts at a glance
- LOINC
- 103978-3
- Short code
- INFORMATION-TO-TELL-DOCTORS-IF-YOU-HAVE-A-SUDDEN-INJURY-OR-ILLNESS-WITH-A-GOOD
- Synonyms
- —
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- reported
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why hs-CRP Matters in Sudden Illness or Injury
hs-CRP (high-sensitivity C-reactive protein) is a blood test that helps doctors detect subtle signs of inflammation—even when other symptoms aren’t obvious. It’s particularly useful after sudden injuries or illnesses because inflammation can occur before you feel symptoms like pain or fever.
How the Test Works
Your blood sample is tested for tiny amounts of CRP, a protein produced by your liver in response to inflammation. The test uses a sensitive method to measure these levels, often in milligrams per liter (mg/L).
When Your Doctor Might Order This Test
Doctors may order hs-CRP if you’ve had a recent injury (like a broken bone or soft tissue trauma), surgery, or illness (such as a viral infection or flare-up of a chronic condition). It can also help monitor long-term inflammation in conditions like heart disease or autoimmune disorders.
What the Results Mean
Results are typically reported as a numerical value, but your doctor will interpret them based on your overall health and symptoms. Very high levels may indicate severe inflammation, while low levels suggest minimal inflammation. Your doctor will discuss what your result means in the context of your care plan.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Inflammation as a Hidden Risk Factor
Short name
hs-CRP
Frequently asked questions
What causes elevated CRP levels?
Can I lower my CRP levels naturally?
How soon after an injury or illness should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy