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Serum/plasma mass concentration of albumin (total protein-related, protein electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein content in your blood, broken down into specific protein fractions, including albumin. Albumin is a key protein that helps maintain fluid balance and supports immune function.

Quick summary

["Albumin and protein fractions help assess kidney function, nutritional status, and overall protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47316-5
Short code
Inner ear 68kD Ab SerPl IA-aCnc
Synonyms
Inner ear 68kD Ab SerPl IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Albumin and Protein Fractions Matter

Albumin is one of the most abundant proteins in your blood and plays a critical role in keeping fluids where they need to be (like in your blood vessels) rather than leaking into tissues. Low albumin levels can signal problems like kidney disease, malnutrition, or liver issues. The other protein fractions (like globulins) help fight infections and transport substances like hormones and vitamins. Together, these measurements give doctors insight into how well your body is producing and balancing proteins.

How This Test Works

This test uses a technique called electrophoresis to separate different protein types in your blood sample. The sample is placed in an electric field, causing proteins to move at different speeds based on their size and charge. The result is a graph showing the distribution of these proteins, including albumin and other fractions. This helps identify any imbalances that might need further investigation.

What the Results Could Indicate

If your albumin levels are too low, it might mean your body isn’t making enough albumin, which could be due to liver disease, kidney problems, or poor nutrition. High levels of certain globulins might suggest chronic infections, inflammation, or autoimmune conditions. Doctors use these results to guide treatment plans, especially for conditions like kidney disease, liver disorders, or immune-related illnesses.

Common Conditions Monitored

Doctors often check albumin and protein fractions in people with kidney disease, liver problems, malnutrition, or chronic infections. These tests can also help monitor how well treatments are working for conditions like cirrhosis, nephrotic syndrome, or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Albumin Profile (Serum/Plasma)

Frequently asked questions

What does a low or high protein fraction mean for my health?
Low albumin levels may indicate malnutrition, liver disease, or kidney problems, while abnormal globulin levels could signal chronic infections, autoimmune diseases, or other inflammatory conditions. Your doctor will discuss these results in the context of your overall health and any symptoms you’re experiencing.
How often should I get this test?
The frequency depends on your health condition. If you have a chronic illness like kidney disease or liver disease, your doctor may recommend regular monitoring. Otherwise, this test is often part of routine blood work or when symptoms suggest a protein imbalance.
Can I prepare for this test differently based on the protein fractions being checked?
No specific preparation is needed for protein electrophoresis, but avoid heavy meals or alcohol before your blood draw. If you’re on certain medications (like steroids), let your doctor know, as they may affect protein levels.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy