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Inosine-to-Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures inosine relative to creatinine to help evaluate purine metabolism.

Quick summary

["This test looks for abnormal inosine levels that may reflect a disorder of purine metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
59210-5
Short code
Inosine/Creat Ur-sRto
Synonyms
Inosine/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures inosine, a compound involved in purine metabolism, in urine. The result is compared with the amount of creatinine in the same urine sample to form an inosine-to-creatinine ratio.

Why might I need this test?

This test may be ordered when a clinician is evaluating a possible inherited or metabolic disorder affecting purine breakdown. It can also help assess abnormalities in inosine excretion.

How is the test performed?

A urine specimen is collected and analyzed in the laboratory. The laboratory measures the amounts of inosine and creatinine and calculates their ratio.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional. Urine may be collected as a clean-catch sample or as a timed sample, depending on the test; label and date the container and store or transport it as instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine inosine/creatinine ratio

Frequently asked questions

Is fasting required for this test?
Fasting is generally not required, but your clinician may give specific diet or collection instructions. Follow the instructions provided with the test order.
Why is creatinine measured along with inosine?
Creatinine is used as a reference for urine concentration. Comparing inosine with creatinine helps reduce the effect of variations in how concentrated or dilute the urine sample is.
What does an abnormal result mean?
An abnormal ratio may suggest a change in purine metabolism, but it does not identify a specific disorder by itself. Your clinician will consider the result alongside symptoms, medications, diet, and other tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy