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Free Inositol/Creatinine Ratio, 5-Hour Urine — Post-Glucose Solution

Published: August 9, 2026Updated: August 16, 2026

Measures free inositol relative to creatinine in urine collected for 5 hours after a prescribed glucose solution is given.

Quick summary

["This urine test shows how much free inositol is released in the urine after a glucose load, adjusted for urine concentration."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76135-3
Short code
Inositol Free/Creat p sug sol 5h Ur-sRto
Synonyms
Inositol Free/Creat p sug sol 5h Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures free inositol, a sugar alcohol involved in cellular signaling, in a timed 5-hour urine collection. The result is divided by the urine creatinine level to help account for differences in urine concentration.

Why might I need this test?

It may be ordered to evaluate how the kidneys handle glucose and related substances after a glucose load, particularly in connection with an oral glucose tolerance evaluation. Your clinician will interpret it alongside blood glucose results, symptoms, medications, and pregnancy status when relevant.

How is the test performed?

After the prescribed glucose solution is given, all urine produced during the specified 5-hour period is collected and tested. The laboratory measures free inositol and creatinine and reports their ratio.

How do I prepare for the test?

Follow the exact instructions provided for the glucose solution and collection period. Record the start and end times, collect every urine sample in the container provided, and tell the laboratory if any sample is missed. Ask whether the container should be refrigerated and whether dietary or medication changes are needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An elevated ratio may indicate increased urinary excretion of free inositol, which can occur with altered glucose metabolism. Results are not diagnostic by themselves and must be interpreted with blood glucose findings, kidney function, medication use, symptoms, and the adequacy of the urine collection.

Short name

5-Hour Urine Free Inositol/Creatinine Ratio

Frequently asked questions

What is free inositol?
Free inositol is a sugar alcohol that participates in cellular signaling, including pathways related to insulin. It is present in the body and can be measured in urine.
Why is the result reported relative to creatinine?
Urine concentration can vary widely. Creatinine is used as an adjustment factor so the inositol result is less affected by how concentrated or dilute the urine sample is.
Can this test diagnose diabetes?
No. It is usually interpreted together with blood glucose testing and other clinical information rather than used alone to diagnose diabetes or another condition.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy