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Insulin concentration in serum measured over a 24-hour period following meals (24-hour postprandial insulin profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures how your body responds to insulin after eating, helping assess how well your pancreas produces insulin to manage blood sugar levels.

Quick summary

["Understanding your insulin response after meals can help diagnose or monitor conditions like diabetes or insulin resistance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95116-0
Short code
Insulin 30M p meal SerPl-aCnc
Synonyms
Insulin 30M p meal SerPl-aCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
2.6
Ref high
24.9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83525
SNOMED
413618004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of diabetes, such as frequent thirst, fatigue, or unexplained weight changes. It may also be used to evaluate how well your current diabetes treatment is working or to check for conditions like hypoglycemia (low blood sugar) or insulin resistance.

How the Test Works

Blood samples are collected at multiple time points (typically after meals) over a 24-hour period. Each sample measures insulin levels in your serum, which helps create a profile of how your body handles insulin post-meal.

Sample Collection Process

You’ll likely be asked to follow a specific diet or fasting instructions before the test. Blood samples are drawn at scheduled times, often including after meals, to capture insulin levels throughout your day.

What to Expect Before the Test

Prepare by discussing any medications or supplements you take, as they may affect insulin levels. Avoid smoking or consuming alcohol before testing, as these can influence results.

Reference range

Fasting: 2.6-24.9 μIU/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Frequently asked questions

How does this test help doctors diagnose or manage diabetes or related conditions?
This test helps identify whether your body produces enough insulin after meals, which is critical for diagnosing type 1 or type 2 diabetes, insulin resistance, or reactive hypoglycemia. It also helps tailor treatment plans, such as adjusting insulin doses or dietary recommendations.
What do abnormal results mean?
Low insulin levels after meals might indicate insufficient insulin production or poor response to glucose, while high levels could suggest overproduction, insulin resistance, or other metabolic issues. Your doctor will interpret results in the context of your overall health and symptoms.
How often should I get this test?
This test is typically done once or twice a year for patients with diabetes to monitor treatment effectiveness. Your doctor will determine the frequency based on your specific needs, such as whether you have stable or fluctuating blood sugar levels.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy