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Insulin with 24-Hour Mean Plasma Glucose (i-MGD) Profile

Published: August 9, 2026Updated: August 16, 2026

This test measures insulin levels alongside your average blood sugar over 24 hours to assess how your body manages glucose and insulin over time, often used in diabetes care.

Quick summary

["Helps diagnose and monitor diabetes and insulin resistance by linking insulin production to blood sugar trends."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55497-2
Short code
Insulin 3M p Glc IV SerPl-sCnc
Synonyms
Insulin 3M p Glc IV SerPl-sCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
2.6
Ref high
24.9
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
83525
SNOMED
413618004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of diabetes (like frequent urination, extreme thirst, or fatigue) or if you have a family history of diabetes. It’s also used to evaluate how well your body responds to insulin, especially in people with type 2 diabetes or prediabetes.

How the Test Works

Blood is drawn at multiple times over 24 hours to measure insulin levels and your blood glucose. The results help create a profile showing how your insulin and glucose interact throughout the day.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid certain foods or medications for a short time. Wear comfortable clothing for blood draws, and plan to stay near the testing site for the full 24 hours.

What the Results Mean

The test provides a detailed picture of how your body produces and uses insulin relative to your blood sugar levels. Abnormal patterns may indicate insulin resistance, diabetes, or other metabolic conditions that need medical attention.

Reference range

Fasting: 2.6-24.9 μIU/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Insulin-Glucose Profile

Frequently asked questions

How long does the blood collection process take?
Blood samples are drawn at several points over 24 hours, typically including morning, afternoon, and evening times. You’ll need to stay at the testing site or have a partner assist you with frequent visits for comfort and safety.
Will I need to change my diet before the test?
You may be advised to follow a standard diet or avoid certain foods/medications for a short period before testing, depending on your doctor’s instructions. Always follow their specific guidance to ensure accurate results.
Can I take my usual medications during the test?
Some medications may affect blood sugar or insulin levels. Ask your doctor before the test if you’re unsure whether to continue taking your usual medications or if adjustments are needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy