Human Insulin Antibody, Serum — Arbitrary Concentration
Measures antibodies that bind human insulin in a blood sample. Results can help explain insulin resistance or unpredictable blood glucose control.
["Human insulin antibodies may interfere with insulin treatment and contribute to unstable blood glucose."]
Key facts at a glance
- LOINC
- 8074-7
- Short code
- Insulin Human Ab Ser-aCnc
- Synonyms
- Insulin Human Ab Ser-aCnc
- Category
- hormone
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 2.6
- Ref high
- 24.9
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 83525
- SNOMED
- 413618004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This blood test measures antibodies directed against human insulin. These antibodies can bind insulin and change how long it works or how effectively it lowers blood glucose.
Why might I need this test?
Your clinician may order this test when blood glucose is difficult to control, when insulin needs are unexpectedly high or low, or when insulin resistance is suspected. It may also be used when insulin treatment does not produce the expected response.
How is the test performed?
A blood sample is drawn from a vein and tested in the laboratory to determine the amount of human insulin antibodies present. No radioactive tracer or other special procedure is involved.
How do I prepare for the test?
Specific preparation may vary by laboratory. Tell the healthcare team about all insulin products you use, including the type and timing of doses, and follow any instructions about fasting or medication timing. Do not stop insulin or other diabetes medicines unless your clinician directs you to do so.
Reference range
Fasting: 2.6-24.9 μIU/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Higher amounts of human insulin antibodies may occur with autoimmune diabetes, insulin resistance, frequent exposure to injected human insulin, or use of certain insulin delivery methods. Antibodies can reduce insulin effectiveness or cause delayed or prolonged insulin action, potentially contributing to poor or unpredictable glucose control. A positive result must be interpreted with symptoms, diabetes history, medication use, and other glucose tests.
Short name
Human Insulin Antibody
Frequently asked questions
Does this test measure the amount of insulin in my blood?
Can human insulin antibodies make diabetes harder to manage?
Do I need to stop using my insulin before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy