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Insulin-Specific IgE Antibody, Qualitative

Published: August 9, 2026Updated: August 16, 2026

A qualitative blood test for IgE antibodies directed against human insulin, used to help evaluate a possible immediate insulin allergy.

Quick summary

["A positive result supports an IgE-mediated insulin allergy, but it must be interpreted with your symptoms and medical history."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6148-1
Short code
Insulin Human IgE Qn
Synonyms
Insulin Human IgE Qn
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
2.6
Ref high
24.9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83525
SNOMED
413618004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test looks for insulin-specific IgE antibodies in your blood. These antibodies are part of the immune reaction that can occur in people with an immediate allergy to insulin.

Why might I need this test?

Your clinician may order this test if you developed hives, swelling, wheezing, or other sudden symptoms after receiving insulin. It may also be used when the cause of an allergic reaction is unclear.

How is the test performed?

A blood sample is analyzed for insulin-specific IgE using a laboratory antibody assay. The result is reported as positive or negative rather than as a measured concentration.

How do I prepare for the test?

Fasting is generally not required for this test. Tell your clinician about the timing and symptoms of your reaction, and do not stop or change insulin treatment without medical guidance.

Reference range

Fasting: 2.6-24.9 μIU/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Insulin-specific IgE

Frequently asked questions

Does a positive result mean I am allergic to insulin?
It supports an immediate insulin allergy, but the result must be interpreted with your symptoms and medical history. Some people may have antibodies without having a clinically significant reaction.
What symptoms can suggest an insulin allergy?
Possible symptoms include hives, itching, swelling, wheezing, or other sudden allergic-type symptoms after insulin exposure. A clinician should evaluate a suspected reaction promptly.
Can I stop insulin if this test is positive?
Do not stop insulin without instructions from your clinician. Unnecessary interruption can be dangerous, particularly if you use insulin to control diabetes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy