Human Insulin IgG4 Antibodies — Mass Concentration
A test that measures IgG4 antibodies directed against human insulin, which may help evaluate unusual insulin allergy or resistance after insulin exposure.
["Elevated human insulin IgG4 antibodies may help explain selected cases of insulin allergy or insulin resistance."]
Key facts at a glance
- LOINC
- 56292-6
- Short code
- Insulin Human IgG4-mCnc
- Synonyms
- Insulin Human IgG4-mCnc
- Category
- hormone
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 2.6
- Ref high
- 24.9
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 83525
- SNOMED
- 413618004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures IgG4 antibodies that recognize human insulin. It is different from a test that measures the amount of insulin in the blood.
Why might I need this test?
Your clinician may order it when allergic symptoms, low blood sugar, or unexpectedly high insulin requirements occur after exposure to human insulin. It may also be used to investigate unexplained insulin resistance.
How is the test performed?
A laboratory sample is analyzed to determine the concentration of human insulin-specific IgG4 antibodies. The result is reported as a mass concentration, meaning the amount of antibody in the tested sample.
How do I prepare for the test?
Special preparation is usually not required, but follow your clinician's instructions about test timing and insulin use. Do not stop or change insulin therapy without medical guidance, especially if you use insulin to treat diabetes.
Reference range
Fasting: 2.6-24.9 μIU/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A higher concentration of human insulin IgG4 antibodies may occur after exposure to human insulin and can be associated with selected cases of insulin allergy or reduced insulin effectiveness. The finding must be interpreted with your symptoms, medical history, other laboratory results, and the type and timing of insulin you use. A positive result alone does not establish a diagnosis.
Short name
Human insulin IgG4 antibodies
Frequently asked questions
Does this test measure my insulin level?
What symptoms might lead to this test being ordered?
Does a positive result mean I am allergic to insulin?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy