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Insulin concentration measured in relation to glucose levels (previously called Insulin-Glucose Profile or Insulin-Glucose Ratio)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates how your body’s insulin levels respond to glucose, helping assess insulin sensitivity and potential diabetes or metabolic disorders.

Quick summary

["Helps diagnose or monitor conditions like insulin resistance or type 2 diabetes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47668-9
Short code
Insulin pre Glc SerPl-aCnc
Synonyms
Insulin pre Glc SerPl-aCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
2.6
Ref high
24.9
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
83525
SNOMED
413618004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of high blood sugar (e.g., frequent urination, excessive thirst) or if you’re at risk for diabetes. It may also be used to check how well insulin is working in people with known diabetes or prediabetes.

How the Test Works

A blood sample is taken to measure insulin levels *simultaneously* with glucose levels. This helps determine how your body regulates blood sugar, especially in response to insulin.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if glucose levels are measured separately. Wear comfortable clothing for blood draws.

What the Results Mean

Results compare insulin and glucose ratios to identify patterns, such as whether insulin is insufficient or ineffective at lowering blood sugar. Abnormal results may signal metabolic issues needing further evaluation.

Reference range

Fasting: 2.6-24.9 μIU/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Insulin-Glucose Profile

Short name

Insulin-Glucose Profile (Serum/Plasma)

Frequently asked questions

How does this test differ from a standard glucose test?
Unlike a single glucose measurement, this test provides a snapshot of insulin’s role in glucose metabolism, offering deeper insight into insulin sensitivity or resistance.
What if my results are outside normal ranges?
If results suggest insulin dysfunction, your doctor may recommend additional tests (e.g., oral glucose tolerance test) or lifestyle changes to manage blood sugar levels.
Can I take insulin before this test?
No, if instructed, avoid taking insulin or other diabetes medications for 24 hours before the test to get an accurate reading.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy