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Intestinal Goblet Cell IgA, Serum, Qualitative

Published: August 9, 2026Updated: August 16, 2026

This test looks for a type of antibody (IgA) in the blood that targets intestinal goblet cells. It is used as a supporting marker when evaluating certain autoimmune intestinal conditions.

Quick summary

["A positive result can support the suspicion of an autoimmune intestinal disorder but must be interpreted alongside symptoms, biopsy, and other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107490-5
Short code
Intestinal goblet cell IgA Ser Ql IF
Synonyms
Intestinal goblet cell IgA Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects immunoglobulin A antibodies directed against goblet cells, which are the mucus-producing cells lining the intestine. A qualitative result simply reports whether these antibodies appear to be present or absent rather than giving an exact amount.

Why It May Be Ordered

Your clinician may order this test when trying to evaluate chronic diarrhea, unexplained intestinal inflammation, or a suspected autoimmune condition affecting the gut. It is generally used as one piece of a larger diagnostic workup rather than on its own.

How the Sample Is Collected

A standard blood draw from a vein in your arm is used to obtain the serum sample. No special preparation is usually required, though you should follow any specific instructions your laboratory or care team provides.

What Results Can Mean

A positive result suggests these antibodies are present and may point toward an autoimmune intestinal process, but it does not confirm a diagnosis by itself. A negative result makes such a condition less likely but also does not rule it out. Results are always interpreted with your symptoms, imaging, biopsy findings, and other laboratory tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Goblet cell IgA antibodies are studied mainly as a marker in autoimmune enteropathy and related conditions in which the immune system targets the intestinal lining. Because these antibodies are not entirely specific, they are most useful when combined with clinical history, endoscopic biopsy, and additional serologic testing. Treatment decisions should never rest on this single result.

Short name

Goblet Cell IgA Antibody

Frequently asked questions

Does a positive result mean I definitely have an intestinal disease?
No. A positive result only shows that the antibodies were detected and may support further evaluation. Your doctor will consider it together with your symptoms, physical exam, biopsy, and other tests before making any diagnosis.
Do I need to fast before this blood test?
In most cases fasting is not required for an antibody test of this kind. However, follow any instructions your ordering provider or laboratory gives you, since preparation can vary by facility.
Can medications affect the result?
Some treatments, especially those that suppress the immune system, could potentially influence antibody levels. Tell your care team about all medicines, supplements, and recent treatments so the result can be interpreted correctly.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy