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Coagulation Function Profile (Plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures several blood components involved in clotting to assess your body’s ability to form blood clots safely and effectively.

Quick summary

["Helps diagnose bleeding or clotting disorders by checking key clotting factors and function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
72661-2
Short code
Intrnsc coag fctr act pnl PPP
Synonyms
Intrnsc coag fctr act pnl PPP
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
2
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test evaluates multiple clotting factors, including prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen levels, and possibly thrombin time or fibrin degradation products, depending on the lab’s specific panel. These measures help identify abnormalities in blood clotting pathways.

Common Conditions Monitored

This panel is often used to monitor conditions like bleeding disorders (e.g., hemophilia), clotting disorders (e.g., deep vein thrombosis risk), liver disease (which affects clotting factor production), or after treatments like anticoagulants (e.g., warfarin). It may also be used pre- and post-surgery to assess clotting risks.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in the arm. Plasma is separated from blood cells and used for testing. If you’re on anticoagulant medication, your doctor may adjust timing to ensure accurate results.

When You Might Need This Test

Your doctor may recommend this test if you have symptoms like excessive bleeding, unexplained bruising, prolonged bleeding after cuts, or if you’re at higher risk for clots (e.g., after surgery, heart disease, or long periods of immobility).

Reference range

NCBI: SCC <2.0 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Coagulation Panel

Frequently asked questions

Why might my results be abnormal?
Abnormal results could indicate bleeding disorders (e.g., low fibrinogen or prolonged PT/aPTT), liver disease (reduced clotting factors), or clotting disorders (e.g., high fibrin degradation products). Your doctor will discuss findings in relation to your symptoms and medical history.
How do I prepare for this test?
Avoid heavy meals 2 hours before testing. If you’re on blood thinners, follow your doctor’s instructions—some may need to stop or adjust timing. Fasted or non-fasted status may vary; check with your lab.
What do I do if I have a bleeding disorder?
If you have a known bleeding disorder, your doctor may recommend specific monitoring or treatments. Follow their guidance closely, especially before procedures or surgeries. Some medications (like aspirin) can affect clotting—ask your doctor about safe alternatives.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy