Serum Iron with Proportionate Non-Saturated Binding Capacity (Iron-NSBC Ratio)
This test measures your body’s iron levels and how much of your iron is available to bind with proteins, helping assess iron status and potential deficiencies or overloads.
["This test helps diagnose iron-related blood disorders by evaluating iron availability and binding capacity in your serum."]
Key facts at a glance
- LOINC
- 75689-0
- Short code
- Iron Pnl SerPl
- Synonyms
- Iron Pnl SerPl
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 60
- Ref high
- 170
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 83540
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Iron is an essential mineral for making red blood cells and maintaining energy levels. If your body doesn’t have enough iron, you may develop anemia or fatigue. This test helps determine if your iron levels are too low or too high, which can affect your overall health.
What to Expect Before the Test
No special preparation is needed for this test. You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes, and you may feel a slight pinch. If you’re on blood thinners or have a history of bleeding, let your healthcare provider know before the test.
What the Results Mean
The results combine your serum iron levels with a measure of how much iron is bound to proteins in your blood. Low results may indicate iron deficiency, while high results could suggest iron overload or other conditions. Your doctor will interpret these results in the context of your overall health.
Common Conditions This Test Helps Diagnose
This test is often used to diagnose iron deficiency anemia, hemochromatosis (iron overload), or other conditions affecting iron metabolism. It can also help monitor treatment for these conditions.
Reference range
NCBI: Serum Iron Male 65-180; Female 50-170 µg/dLN/A
Fasting for 12 hours preferred. Iron supplements should be stopped 24 hours before if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Iron and Binding Capacity Test
Frequently asked questions
How often do I need this test?
What are the typical reference ranges for this test?
Can I eat or drink anything before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy