Serum Iron and Transferrin Saturation (Iron Binding Capacity)
This test measures two key parts of your body’s iron balance: how much iron is in your blood and how well your protein called transferrin can carry iron.
["Helps assess iron deficiency or overload, which can affect energy and health."]
Key facts at a glance
- LOINC
- 13452-8
- Short code
- Iron/Transferrin SerPl
- Synonyms
- Iron/Transferrin SerPl
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 60
- Ref high
- 170
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 83540
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why It’s Done
Your doctor may order these tests if you have symptoms like fatigue, pale skin, unusual tiredness, or if they suspect conditions like anemia, hemochromatosis (iron overload), or other blood disorders. They might also check iron levels if you’re pregnant, have frequent infections, or have an unusual appetite for non-food items (pica).
What to Expect
A small blood sample is taken from a vein in your arm. The blood is sent to a lab where it’s analyzed to measure iron levels and how much of your transferrin protein is saturated with iron. Results help determine if you need iron supplements or other treatments.
Normal vs. Abnormal Results
There are no standard reference ranges provided here since they can vary by lab. Your results will be interpreted by your healthcare provider based on your overall health and symptoms. Low results may indicate iron deficiency, while high results could suggest iron overload or other conditions.
Common Conditions Linked to These Tests
Low iron levels (low iron or high transferrin saturation) often point to anemia or iron deficiency, which can cause fatigue, weakness, or pale skin. High iron levels (low transferrin saturation) may indicate hemochromatosis or other iron storage disorders. These tests also help monitor conditions like chronic kidney disease or certain infections.
Reference range
NCBI: Serum Iron Male 65-180; Female 50-170 µg/dLN/A
Fasting for 12 hours preferred. Iron supplements should be stopped 24 hours before if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Iron Studies (Serum)
Frequently asked questions
What questions might you have about this test?
How long will it take to get my results?
Can I take iron supplements without checking my levels first?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy