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Autoimmune Antibody Profile for Islet Cell Antibodies (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies that may indicate an autoimmune response targeting pancreatic islet cells, often linked to type 1 diabetes development.

Quick summary

["Helps assess risk for autoimmune-related diabetes or other islet-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109992-8
Short code
Islet Cell512 Ab Msmt Ser
Synonyms
Islet Cell512 Ab Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

The test detects the presence of antibodies directed against islet cells in your blood. These antibodies can signal an immune system attack on insulin-producing cells in the pancreas, which may lead to diabetes or other autoimmune disorders.

Why Might You Need This Test?

This test may be ordered if you have symptoms of diabetes, a family history of type 1 diabetes, or other autoimmune conditions. It can also be used in research or monitoring for individuals at higher risk.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion is then analyzed using an immunoassay method to detect specific antibodies against islet cell antigens.

What Does a Positive Result Mean?

A positive result suggests an autoimmune response targeting pancreatic islet cells, which may increase the risk of developing type 1 diabetes or other related conditions. Further evaluation by a healthcare provider is needed for diagnosis or management planning.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Islet Cell Antibodies (Serum)

Frequently asked questions

What are the typical reference ranges for this test?
Reference ranges are not standardized for islet cell antibodies due to variability in immunoassay methods and clinical contexts. Results are interpreted in the context of your symptoms, medical history, and overall health.
How long does it take to get results from this test?
Results are typically available within 2–5 business days, depending on lab processing times and your healthcare provider’s workflow.
Can lifestyle changes affect this test result?
While diet, exercise, or other lifestyle factors may influence autoimmune activity in general, they do not directly alter the detection of islet cell antibodies. Your healthcare provider will consider all relevant factors when interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy