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Autoantibody Panel to Screen for Islet Cell Antibodies (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies that may indicate an autoimmune response targeting pancreatic beta cells, often linked to type 1 diabetes. It helps identify early signs of islet cell destruction.

Quick summary

["This screening may help detect potential diabetes risk before symptoms appear."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31209-0
Short code
Islet Cell512 Ab Ser-aCnc
Synonyms
Islet Cell512 Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

The test detects the presence of islet cell antibodies in your blood. These antibodies are produced by the immune system when it mistakenly targets healthy cells in the pancreas, which produce insulin. This screening is part of a broader evaluation for autoimmune diabetes.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms like unexplained weight loss, frequent thirst, or unexplained fatigue, or if you have a family history of type 1 diabetes. It can also be used in research or specialized settings to monitor autoimmune conditions.

How Is the Sample Collected?

A small blood sample will be drawn from a vein in your arm by a healthcare professional. The sample is then sent to a lab for analysis.

What Does a Positive Result Mean?

A positive result suggests the presence of islet cell antibodies, which may indicate an autoimmune process affecting pancreatic cells. This does not confirm diabetes but may prompt further testing or monitoring.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Islet Cell Antibodies and Autoimmune Diabetes

Short name

Islet Cell Antibody Screening

Frequently asked questions

What are the possible causes of abnormal results?
Abnormal results may be due to an autoimmune response, though other conditions or factors could influence antibody levels. Follow-up testing, such as C-peptide levels or genetic screening, may be recommended to better understand your health status.
How soon will I get my results?
Results are typically available within 1 to 3 business days, depending on lab processing times. Your healthcare provider will discuss the results with you during your follow-up visit.
Can I prepare for this test?
No special preparation is needed. However, inform your healthcare provider about any medications you’re taking, as some may affect test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy