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Islet Cell Antibody Titration (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies that may target cells in the pancreas, often linked to autoimmune conditions affecting insulin production.

Quick summary

["Helps assess potential diabetes-related autoimmune disorders by detecting specific antibodies in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32636-3
Short code
Islet Cell512 Ab Titr Ser
Synonyms
Islet Cell512 Ab Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms of diabetes or related autoimmune diseases, such as persistent nausea, unexplained weight loss, or unexplained fatigue. It may also be used in patients with type 1 diabetes who have unexplained rapid progression or complications.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from a vein in your arm. If you’re on blood thinners, inform your healthcare provider beforehand.

What the Results Mean

Positive results suggest the presence of islet cell antibodies, which may indicate an autoimmune response targeting pancreatic cells. Results alone don’t diagnose diabetes but guide further evaluation.

Common Conditions Linked to Positive Results

Positive findings are often seen in type 1 diabetes or related autoimmune conditions like insulinoma (a rare pancreatic tumor). They may also appear in other autoimmune disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Islet Cell Antibody (ICA) Test

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of islet cell antibodies, which may suggest an autoimmune process affecting your pancreas. This doesn’t confirm diabetes but signals a need for further evaluation, including blood glucose monitoring and possible additional tests.
Lifestyle factors like diet, exercise, or stress may influence blood test results indirectly (e.g., blood sugar levels), but they do not directly alter antibody levels measured in this test. Always follow your doctor’s advice for managing related conditions.
Your doctor will determine the frequency based on your symptoms, medical history, and diagnosis. Some patients may need retesting if symptoms worsen or if new autoimmune concerns arise.
Is this test covered by insurance?
Coverage depends on your insurance plan and medical necessity. Check with your provider or insurance company to confirm if this test is included under your benefits, especially if related to a diagnosed or suspected autoimmune condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy