Autoimmune Antibody Panel (Islet Cell Antibodies, Serum)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained weight loss, frequent thirst, or unexplained fatigue, especially if you have a family history of diabetes or autoimmune diseases. It may also be used to monitor conditions like autoimmune pancreatitis or other pancreatic autoimmune disorders.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw blood, and you can continue with your normal activities afterward. If you’re on blood thinners, let your provider know before the test.

What the Test Results Mean

Positive results suggest the presence of antibodies against pancreatic islet cells, which may indicate an autoimmune process. However, elevated levels alone don’t confirm diabetes or another condition—results are usually interpreted alongside clinical findings and other tests.

Common Reasons for Testing

This test is often part of a broader evaluation for suspected autoimmune diabetes (type 1 diabetes) or other pancreatic autoimmune disorders. It may also be used in research or specialized clinical settings to assess immune-mediated pancreatic damage.