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Total Isocyanate Exposure Level (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total level of isocyanates, a group of chemicals used in adhesives, coatings, and sealants, in your blood serum. Isocyanates can cause allergic reactions and respiratory issues.

Quick summary

["Assesses potential exposure to harmful isocyanate chemicals in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61277-0
Short code
Isocyanate HDI IgE/IgE total %
Synonyms
Isocyanate HDI IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test is done to find out whether you have been exposed to a harmful substance and to measure how much of it may be present in your body, so your doctor can decide on the right follow-up care and treatment plan.

Your healthcare provider may order this test if you work with or are exposed to isocyanates, have symptoms like skin rashes, breathing difficulties, or unexplained allergic reactions. It can also help monitor long-term exposure risks.

Before the test, tell your doctor about any medications, vitamins, or supplements you take, as well as any recent illnesses or possible contact with harmful substances at home or at work. In most cases you can eat and drink normally beforehand, and your care team will explain exactly where to go and what will happen during your visit.

No special preparation is needed. You’ll provide a blood sample, typically drawn from a vein in your arm. The process takes a few minutes, and you can resume normal activities afterward.

Your results show the level of the substance found in your blood. A normal level usually means no significant exposure, while a higher level may suggest recent or ongoing exposure. Your doctor will interpret your numbers along with your symptoms and medical history, and may order repeat testing to confirm the findings before recommending any treatment.

Results help determine if you’ve been exposed to harmful levels of isocyanates. High levels may indicate recent or ongoing exposure, which could affect your health over time.

Exposure often happens through contact with contaminated soil, dust, old paint, or tainted drinking water, as well as through certain jobs such as construction or manufacturing, hobbies like welding or pottery, and some foods, imported products, or traditional remedies that may contain harmful substances.

Exposure often occurs in industries like manufacturing, construction, or automotive repair where adhesives, paints, or sealants containing isocyanates are used. Occupational settings are the most common sources.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is primarily used for occupational health screening to identify potential risks from isocyanate exposure. Elevated levels may prompt further evaluation for allergic reactions, respiratory conditions, or long-term health monitoring.

Short name

Isocyanate Exposure Test

Frequently asked questions

What triggers this test?
Your doctor may recommend it if you have a history of exposure to isocyanates, symptoms like skin irritation, asthma, or unexplained allergic reactions, or if you work in industries where these chemicals are present.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab and insurance processing times.
Can I fast before this test?
No fasting is required for this blood test, so you may eat and drink as you normally would before your appointment, and there are no special preparations you need to make ahead of time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy