Total Serum Isocyanate Concentration (24-Hour Urine)
This test measures the total amount of isocyanates, a group of chemicals used in adhesives, coatings, and sealants, over a 24-hour period in your urine. Isocyanates can cause skin and respiratory irritation and may pose long-term health risks if exposure is frequent.
["Assessing long-term exposure to harmful chemicals from workplace or household products."]
Key facts at a glance
- LOINC
- 61278-8
- Short code
- Isocyanate TDI IgE/IgE total %
- Synonyms
- Isocyanate TDI IgE/IgE total %
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 86038
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test if you work in industries involving isocyanates (e.g., automotive, construction, or manufacturing) or if you experience symptoms like persistent coughing, skin rashes, or breathing difficulties. It helps evaluate potential occupational or environmental exposure.
What to Expect During the Test
You’ll collect all urine for a full 24-hour period in a sterile container. The sample is then sent to a lab for analysis. No special preparation is needed, but drink plenty of water to ensure proper urine flow.
How the Results Are Interpreted
Results are compared to reference ranges for healthy individuals. Elevated levels may indicate recent or ongoing exposure to isocyanates, but interpretation depends on clinical context, including your occupation and symptoms.
Potential Risks and Considerations
While urine collection is simple, improper handling (e.g., contamination) can affect results. If you’re pregnant, have kidney disease, or take certain medications, inform your provider before testing.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Isocyanates and Health
Short name
Total Urine Isocyanate (24h)
Frequently asked questions
What does a high or low result mean?
How often should I get this test?
Can I stop taking supplements or medications before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy