Isoleucine in Cerebrospinal Fluid (CSF) by Substance Concentration
This test measures the amount of the amino acid isoleucine found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). It may be used to evaluate conditions affecting brain chemistry or metabolism.
["Isoleucine levels in CSF can help diagnose or monitor certain neurological or metabolic disorders."]
Key facts at a glance
- LOINC
- 22659-7
- Short code
- Isoleucine CSF-sCnc
- Synonyms
- Isoleucine CSF-sCnc
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why Might This Test Be Ordered?
Your healthcare provider may recommend this test if you have symptoms like seizures, developmental delays, movement disorders, or signs of metabolic disorders. It could also be part of a broader evaluation for conditions like inborn errors of metabolism or neurological diseases affecting amino acid metabolism.
What Does This Test Involve?
A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then sent to the lab for analysis. This test is typically performed under sterile conditions to ensure accuracy.
What Does a Result Mean?
While specific reference ranges can vary by lab, abnormal levels of isoleucine in CSF may suggest underlying metabolic or neurological conditions. Your results will be interpreted by your healthcare provider in the context of your symptoms and medical history.
Common Conditions Monitored or Diagnosed
This test may be used to help diagnose or monitor conditions such as certain aminoacidopathies (inherited metabolic disorders), organic acidemias, or other neurological conditions that affect amino acid metabolism in the brain.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormally high or low levels of isoleucine in CSF could indicate a metabolic or neurological disorder. For example, elevated levels might suggest an accumulation of amino acids due to enzyme deficiencies, while low levels could be part of broader metabolic imbalances. Always discuss results with your healthcare provider to determine the next steps.
Short name
CSF Isoleucine
Frequently asked questions
What preparation is needed before this test?
Is the procedure painful?
How long does it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy