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Total IgE (Immunoglobulin E) Level

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of Immunoglobulin E (IgE) in your blood. IgE is a type of antibody that plays a role in allergic reactions and responses to certain allergens.

Quick summary

["IgE levels help identify allergies or immune system sensitivities."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
61254-9
Short code
Italian Cypress IgE/IgE total %
Synonyms
Italian Cypress IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Immunoglobulin E (IgE)?

IgE is a protein produced by your immune system in response to allergens like pollen, dust mites, or certain foods. While IgE is normal in small amounts, elevated levels may indicate allergies or allergic conditions such as asthma, eczema, or hay fever.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms of allergies (e.g., sneezing, itching, rash) or if you’re being evaluated for conditions like allergic rhinitis, asthma, or other allergic disorders. It can also help monitor treatment progress or rule out other causes of symptoms.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is then sent to a lab for analysis using an immunoassay method to measure IgE levels.

What Do Results Mean?

Results are compared to standard reference ranges, but interpretation depends on clinical context. High IgE levels may suggest allergies, while very low levels might indicate a reduced immune response to allergens. Your doctor will discuss results with you based on your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated IgE Levels

Short name

IgE Total

Frequently asked questions

How often do IgE tests affect treatment plans?
IgE test results alone don’t diagnose allergies—they’re often used alongside other tests (like skin prick tests or blood allergen-specific IgE tests) to guide treatment. If IgE is elevated, your doctor may recommend allergy avoidance strategies, medications, or immunotherapy.
Can IgE levels change over time?
Yes, IgE levels can fluctuate due to allergens, infections, or treatments. Repeated testing may be needed to track changes, especially if you’re undergoing allergy management (e.g., immunotherapy). Always discuss timing with your healthcare provider.
Is there anything I should do before the test?
No special preparation is usually needed, but avoid taking allergy medications (e.g., antihistamines) 24–48 hours before if instructed by your doctor, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy