Skip to content

Total Protein in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein levels and identify potential issues like malnutrition, kidney disease, or liver problems.

Quick summary

["Protein levels can signal health risks or nutritional needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
65324-6
Short code
Jk3 Ab SerPl Ql
Synonyms
Jk3 Ab SerPl Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions affecting protein production, such as liver disease (e.g., cirrhosis), kidney disease (e.g., nephrotic syndrome), or malnutrition. It can also help monitor protein loss due to conditions like burns or chronic inflammation.

What Does a Low or High Protein Level Mean?

Low protein levels may indicate poor nutrition, kidney problems, or liver disease. High protein levels could suggest dehydration, certain infections, or conditions like multiple myeloma (a blood cancer). Your doctor will interpret results in the context of your overall health.

How Is This Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma, where protein levels are measured using a specialized laboratory technique.

What Are Common Causes of Abnormal Results?

Abnormal results can stem from dietary factors (e.g., low protein intake), medical conditions (e.g., liver or kidney disease), or medications. Chronic illnesses like diabetes or inflammatory diseases may also affect protein levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

Why might my doctor ask for this test if I feel healthy?
Even if you feel well, certain conditions—like undiagnosed liver or kidney issues—can cause protein levels to change without obvious symptoms. Routine checks may help catch problems early.
Can diet affect my protein test results?
Yes, diet plays a role. High-protein diets or deficiencies in protein can influence results. Your doctor may recommend dietary adjustments or further testing if needed.
Is there anything I should do before the test?
No special preparation is usually needed, but avoid strenuous activity or eating heavy meals 24 hours before the test to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy